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CBR3 carbonyl reductase 3 [ Homo sapiens (human) ]

Gene ID: 874, updated on 2-Nov-2024

Summary

Official Symbol
CBR3provided by HGNC
Official Full Name
carbonyl reductase 3provided by HGNC
Primary source
HGNC:HGNC:1549
See related
Ensembl:ENSG00000159231 MIM:603608; AllianceGenome:HGNC:1549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hCBR3; SDR21C2; HEL-S-25
Summary
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 6.1), skin (RPKM 5.7) and 22 other tissues See more
Orthologs
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Genomic context

See CBR3 in Genome Data Viewer
Location:
21q22.12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (36135079..36146562)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (34518104..34529412)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (37507377..37518860)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37506732-37507539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37507540-37508346 Neighboring gene CBR3 antisense RNA 1 Neighboring gene MEMO1 pseudogene 1 Neighboring gene ribosomal protein S9 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37527648-37528315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37528316-37528982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13281 Neighboring gene DOP1 leucine zipper like protein B Neighboring gene ribosomal protein L3 pseudogene 1 Neighboring gene uncharacterized LOC124905016

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-keto sterol reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
enables NADPH dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carbonyl reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carbonyl reductase (NADPH) activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phylloquinone catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
carbonyl reductase [NADPH] 3
Names
NADPH-dependent carbonyl reductase 3
carbonyl reductase (NADPH) 3
epididymis secretory protein Li 25
quinone reductase CBR3
short chain dehydrogenase/reductase family 21C member 2
NP_001227.1
XP_011528074.1
XP_054180884.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052818.1 RefSeqGene

    Range
    5179..16662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001236.4NP_001227.1  carbonyl reductase [NADPH] 3

    See identical proteins and their annotated locations for NP_001227.1

    Status: REVIEWED

    Source sequence(s)
    AB041012, BC002812
    Consensus CDS
    CCDS13642.1
    UniProtKB/Swiss-Prot
    O75828, Q6FHP2
    UniProtKB/TrEMBL
    Q53F60, V9HW40
    Related
    ENSP00000290354.5, ENST00000290354.6
    Conserved Domains (1) summary
    cd05324
    Location:6277
    carb_red_PTCR-like_SDR_c; Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    36135079..36146562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529772.3XP_011528074.1  carbonyl reductase [NADPH] 3 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:6131
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    34518104..34529412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324909.1XP_054180884.1  carbonyl reductase [NADPH] 3 isoform X1